Using data from 190,194 COVID-19 patients, the following conditions were found to be most strongly associated with a higher risk of hospitalization and death:
- Heart failure
- A weakened immune system
- A BMI of 40 or higher
Asthma and hypertension were associated with a higher risk of hospitalization, but not death.
The estimates for risk of death align with an NHS study1 that used similar methods in a smaller sample.
Not all comorbidities were present at the time of admission, and some may have been caused by COVID-19. Full methodology and further discussion are included in the linked report.
The data in this analysis were pooled from 45 health systems representing 470 hospitals that span 20 different states and cover 50 million active patients as of May 13, 2020.
1Williamson, E et al. OpenSAFELY: factors associated with COVID-19-related hospital deaths in the linked electronic health records of 17 million adult NHS patients. medRxiv. May 6, 2020. DOI: 10.1101/2020.05.06.20092999